News

1

February

2020

Yujia Qing: “The DCA gave me a unique opportunity to distill my abstract thoughts, which emerged during daily research, into a systematic plan.”

An interview with Yujia Qing (University of Oxford, UK), the winner of the Dream Chemistry Award 2019 with the project “Sequencing Life”.

What was the impulse that brought you to biochemistry?
I was trained as a chemist during my undergraduate studies and later moved on to pharmacology for a master’s degree and chemical biology for my PhD. However, strictly speaking, I am researching on single-molecule chemistry through a biophysical approach. I think it is the interdisciplinary training that eventually led me to an interdisciplinary research theme, which I would call a natural course, and not an impulse.

How was preparing your Dream Chemistry Award project different from your day-to-day research work? Do you feel it gave you anything else than the prize?
Absolutely. In shaping the proposal for the DCA, I got to take a step back and review my research from a distance. It is different from my day-to-day work as I needed to focus on the big picture rather than a specific experimental question. The Dream Chemistry Award gave me a unique opportunity to distill my abstract thoughts, which emerged during daily research, into a systematic plan. This is invaluable as a guide to my future research, even more so than the generous prize money.

Your project dealt with massively parallel single-molecule biopolymer sequencing. How did you come up with it?
I would say the big dream of a massively parallel single-molecule sequencer for biopolymers is always there in the field. I never set out to achieve such an ambitious goal as there were no clear paths towards it. Instead, I started off by investigating chemical reactions of interest at the single-molecule level, which serendipitously provided a potential design for the dream. To be more specific, in studying a specific chemical reaction known as the thiol-disulfide interchange, I established control over its regioselectivity and further exploited it to construct a mobile molecule, termed as the molecular hopper. Our hopper steps directionally on a track of multiple cysteine residues through consecutive regioselective thiol-disulfide interchange while carrying an oligonucleotide cargo. The chemical ratcheting motion exhibited by the hopper is analogous to the enzymatic ratcheting underpinning the nanopore sequencing technology. The step size is comparable to the contour length of individual building blocks in the information-rich biopolymers, such as DNA, RNA, and protein. The simple design of the hopper and its remarkable performance led us to dream that one day, millions of hoppers can work simultaneously on a surface to ratchet diverse individual biopolymers through single-molecule detectors for sequence identification.

How does the research you do and your chemistry dream relate?
My research mainly looks at chemical reactions at the single-molecule level. It is rooted more in basic science as I am curious about how chemistry works between individual molecules and how we can manipulate chemistry in a confinement. My dream, on the other hand, is more application-oriented with the ultimate goal to develop a new generation of biopolymer sequencers. However, I am a firm believer that discoveries made while researching on basic science will pave the way towards new technology. Hopefully, my single-molecule chemistry research will keep inspiring my chemistry dream till it is realised.

How important do you think is imagination and the ability to dream for a scientist?
For scientific research, imagination is the ability to come up with creative solutions to identified problems, often through integrating different research strategies and methods into a research plan. On the other hand, a scientist with the ability to dream has constant motivation to solve the big problems. Therefore, they are very important, if not necessary, for every scientist who aims to push the boundaries of science.

Unlike the other members of the DCA Top 5, you don't run your own research group yet. Is your dream chemistry project what you will pursue once such time comes?
Yes, it is what I would like to pursue once the time comes. One thing I like about my dream chemistry project is that it encompasses many fundamentally interesting questions and all of them come together for a big goal of new technology. I think the first step will be to address the individual basic science questions, such as if we can establish a proof-of-concept for protein sequencing or if we can generate surfaces that allow our chemical machine to move stepwise for a long distance.

How did you enjoy your stay in Prague?
It was absolutely delightful. Prague is a historic city with a vibrant culture, which I believe is necessary to foster the dreaming character of a scientist. As a first-time visitor to Prague, I am also lucky to have experienced the scientific side of this beautiful city by visiting IOCB. I am very impressed by the world-class academics and facilities in the institute and I look forward to future interactions with the brilliant scientists there.

Is there anything else you would like to tell us?
I would like to take the chance to thank my supervisor, Prof. Hagan Bayley. I am very fortunate to have been working with someone who dared to dream big decades ago and now his dream of nanopore sequencing has come true. This really encouraged me to draw up a dream of my own and work with belief to realise it one day.

Archive

6

December

2017

Prague

Winning project of the DCA 2017 focuses on new perspectives for cancer treatment

On 4-5 December 2017, the finale of the international scientific contest Dream Chemistry Award was held in Prague, organized by the leading chemistry institutes of the Czech and Polish Academy of Sciences.

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10

October

2018

Warsaw

Dream Chemistry Award 2018 knows its Finalists

This year’s edition of the Dream Chemistry Award knows its finalists. The Scientific Committee selected top 5 candidates and their projects and invited the authors to Warsaw, Poland, to the finale of the contest which will be held on 3-4 December 2018.

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4

December

2018

Warsaw

Dr. Eric Daniel Glowacki with the Dream Chemistry Award 2018

The winner of the global Dream Chemistry Award competition this year is Dr. Eric Daniel Glowacki from the Linköping University. The Scientific Committee awarding the prize praised the laureate's project on catalysts for the production of clean energy from the hydrogen peroxide.

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5

December

2019

Prague

Dream Chemistry Award 2019 goes to Yujia Qing of University of Oxford

Yujia Qing of University of Oxford has won the 2019 Dream Chemistry Award, an international competition for young scientists that took place on 2-3 December 2019, at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague). In addition to the Dream Chemistry Award statuette, the winner also received two monetary prizes totaling €11,000.

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1

February

2020

Emiliano Cortés: “To have big dreams you need to imagine that things can be different and that you can contribute towards that.”

An interview with Emiliano Cortés (Ludwig Maximilian University in Munich, Germany), the TOP 5 finalist of the Dream Chemistry Award 2019 with the project “Lighting Up Chemical Reaction Pathways”.

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1

February

2020

Jeffrey Martell: “We need to think expansively to identify research goals that others haven't thought of.”

An interview with Jeffrey D. Martell (University of Wisconsin-Madison, USA), the TOP 5 finalist of the Dream Chemistry Award 2019 with the project “DNA Nano-Scaffolds for Rapid Discovery of Enzyme-Mimicking Catalysts”.

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1

February

2020

Hannes Mikula: “The Dream Chemistry Award was an amazing experience.”

An interview with Hannes Mikula (Vienna University of Technology, Austria), the TOP 5 finalist of the Dream Chemistry Award 2019 with the project “Double-targeted In Vivo Synthesis of Drugs at the Site of Disease”.

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1

February

2020

Yoeri van de Burgt: “Imagination and the ability to dream is essential. Most other logical and reasonable ideas have already been tried.”

An interview with Yoeri van de Burgt (Eindhoven University of Technology, Netherlands), the TOP 5 finalist of the Dream Chemistry Award 2019 with the project “Brain-Inspired Organic Modular Lab-on-a-Chip for Cell Classification”.

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1

February

2020

Yujia Qing: “The DCA gave me a unique opportunity to distill my abstract thoughts, which emerged during daily research, into a systematic plan.”

An interview with Yujia Qing (University of Oxford, UK), the winner of the Dream Chemistry Award 2019 with the project “Sequencing Life”.

Continue

8

December

2020

Warsaw

Dreaming big about the smallest things: Dream Chemistry Award 2020

On the 1 December, the jury has announced the winner of this year's Dream Chemistry Award. Because of the pandemic restrictions, the whole event has been carried online.

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